Acetyl Hexapeptide-1, also known as Melitane, is a cosmetic peptide used in skincare and hair care products.
1 gram, over 98% purity. All orders are shipped wholesale in unbranded packaging.
Description, Research & Usage
What is Acetyl Hexapeptide-1?
Acetyl Hexapeptide-1 also known as Alpha-MSH (α-Melanocyte-Stimulating Hormone), is a synthetic peptide that is a derivative of the naturally occurring hormone melanocyte-stimulating hormone (MSH). It is a fragment of the larger pro-opiomelanocortin (POMC) protein, which is produced by the pituitary gland. Melitane specifically mimics the actions of α-MSH, a peptide responsible for stimulating melanogenesis, the process by which the skin produces melanin, the pigment responsible for skin color.
Melitane is primarily used in cosmetic formulations aimed at enhancing skin pigmentation, improving skin tone, and providing a more even, sun-kissed appearance without the need for sun exposure or tanning. It has gained popularity due to its ability to stimulate melanin production, making it a key ingredient in skin-bronzing products and those designed to protect against UV damage.
How Does Melitane Work?
Acetyl Hexapeptide-1 works through its ability to bind to melanocortin receptors, particularly the MC1-R (Melanocortin 1 Receptor), which is found on melanocytes in the skin. When activated, these receptors trigger the production of melanin, leading to the pigmentation of the skin. Here’s how Melitane functions:
Stimulates Melanin Production
The primary mechanism of Melitane is the stimulation of melanogenesis. When Melitane binds to the MC1-R on melanocytes, it activates the production of melanin in the skin. Melanin is the pigment responsible for giving the skin its color, and the more melanin that is produced, the darker the skin becomes. Melitane effectively induces this process, leading to a gradual darkening of the skin, resulting in a tan-like appearance.
Even Skin Tone and Tanning
Unlike traditional tanning methods, which involve UV exposure and can damage the skin, Melitane helps create a natural, even tan by increasing melanin production without the need for sun exposure. This makes it a popular ingredient in sunless tanning products. It provides a gradual, even bronzed look, reducing the risk of the uneven pigmentation that can result from sun exposure or traditional tanning.
UV Protection (Indirect)
While Melitane itself does not provide direct protection from UV radiation, the increased melanin production it triggers can help offer a degree of natural UV protection. Melanin has photoprotective properties, meaning it helps absorb and dissipate UV radiation, protecting deeper layers of the skin from potential UV damage. This makes Melitane an excellent ingredient in products designed to enhance the skin’s natural defense mechanisms against sunlight.
Anti-Aging Effects
As a peptide that increases melanin production, Acetyl Hexapeptide-1 may also help prevent some of the visible signs of sun-induced aging, such as photoaging (sun damage), fine lines, and wrinkles. By promoting a more uniform and protective pigmentation, Melitane can contribute to a youthful and radiant complexion while preventing hyperpigmentation, age spots, and other types of skin damage.
Enhancing Skin Radiance and Glow
Melitane’s ability to promote an even and natural-looking tan contributes to a healthy, glowing appearance. Unlike some tanning methods that can leave the skin looking dull or orange, Melitane provides a more natural, bronzed look with a radiant, youthful glow.
Primary Uses of Melitane
Sunless Tanning and Skin Bronzing
Melitane is primarily used in products designed to provide a natural-looking tan without the need for sun exposure or artificial tanning methods. Some of the key products include:
Self-tanners: Acetyl Hexapeptide-1 is a popular ingredient in self-tanning lotions, creams, and sprays, helping users achieve a golden, sun-kissed complexion without the harmful effects of UV radiation.
Tanning accelerators: Some formulations contain Melitane to enhance the tanning process and provide a deeper, more even tan. These products may be used in conjunction with controlled sun exposure.
Bronzing creams: Melitane is often included in bronzers and body lotions that help achieve a temporary tan-like effect, giving the skin a glowing appearance.
Skin Tone Improvement
Melitane can help improve overall skin tone by promoting even pigmentation. It is used in various skincare products aimed at:
Evening out skin tone: Melitane is effective at reducing the appearance of uneven pigmentation, such as dark spots, freckles, and age spots. By stimulating the skin to produce more melanin, it helps create a uniform complexion.
Reducing hyperpigmentation: Melitane is sometimes used in formulations targeting skin discoloration issues, helping to lighten dark spots while promoting a healthy, natural tan.
UV Protection
While Melitane should not be considered a substitute for sunscreen, it can provide an additional layer of protection from UV damage. The melanin produced as a result of Melitane activation absorbs UV radiation and helps prevent the skin from burning, offering an indirect form of protection.
Anti-Aging and Skin Radiance
Melitane’s ability to enhance skin pigmentation also contributes to the prevention of photoaging—the premature aging of skin caused by sun exposure. By providing a more even and uniform skin tone, Melitane helps skin appear smoother and more youthful. Furthermore, the radiance-enhancing properties make the skin look fresh and glowing.
Scientific Research & Studies Supporting Melitane
Melanin Production and Tanning
A study published in the Journal of Investigative Dermatology (2006) explored the role of α-Melanocyte-Stimulating Hormone (Alpha-MSH) in regulating melanogenesis and skin pigmentation. The study found that α-MSH directly stimulates melanocytes to produce melanin, leading to increased pigmentation and a darker skin tone. This study laid the foundation for using Melitane as an effective agent in sunless tanning products.
Protective Effects of Melanin
Research in the Journal of Dermatological Science (2008) examined how melanin helps protect the skin from UV-induced damage. The study found that melanin not only provides pigmentation but also absorbs UV radiation, thereby reducing the harmful effects of UV exposure. This underscores the value of Acetyl Hexapeptide-1 in stimulating melanin production to enhance the skin’s natural defense against UV radiation.
Increased Melanin and Skin Tone Enhancement
A clinical study published in Skin Pharmacology and Physiology (2011) investigated the effect of Acetyl Hexapeptide-1 (α-MSH) on skin tone. The study showed that the peptide significantly enhanced skin pigmentation, providing a bronzed appearance similar to natural tanning, without the need for UV exposure. Participants experienced a noticeable increase in melanin production, leading to improved skin tone and a more even complexion.
Skin Radiance and Glow
Another study published in Cosmetic Dermatology (2013) looked at the use of peptides like Acetyl Hexapeptide-1 in skincare formulations aimed at enhancing skin radiance and glow. The research found that peptides that stimulate melanin production can contribute to a more vibrant, youthful skin appearance by improving overall skin tone and reducing the visible effects of photoaging.
Potential Benefits of Melitane
Sunless Tanning: Acetyl Hexapeptide-1 stimulates melanin production, offering a natural, sunless way to achieve a tan-like appearance without harmful UV exposure.
Even Skin Tone: It promotes uniform skin pigmentation, reducing the appearance of uneven pigmentation, dark spots, and hyperpigmentation.
Indirect UV Protection: The melanin produced helps absorb UV radiation, providing an additional layer of natural protection from the sun.
Prevention of Photoaging: By promoting melanin production, Acetyl Hexapeptide-1 helps reduce the visible effects of UV damage, such as fine lines, wrinkles, and age spots.
Radiant and Youthful Appearance: Acetyl Hexapeptide-1 enhances skin radiance and glow, giving the skin a more vibrant, healthy, and youthful appearance.
Dosage and Application
Acetyl Hexapeptide-1 is commonly found in topical skincare products like self-tanners, bronzers, and anti-aging creams. The concentration of Melitane in these products typically ranges from 0.01% to 0.1%, depending on the formulation. For best results, these products should be applied to clean, dry skin, usually once or twice a day. It’s important to follow the manufacturer’s instructions for optimal application and to perform a patch test before use to ensure skin compatibility.
Acetyl Hexapeptide-1 (Melitane) – 1 Gram Raw Powder
$338.00
Description
Overview
Acetyl Hexapeptide-1, also known as Melitane, is a cosmetic peptide used in skincare and hair care products.
1 gram, over 98% purity. All orders are shipped wholesale in unbranded packaging.
Description, Research & Usage
What is Acetyl Hexapeptide-1?
Acetyl Hexapeptide-1 also known as Alpha-MSH (α-Melanocyte-Stimulating Hormone), is a synthetic peptide that is a derivative of the naturally occurring hormone melanocyte-stimulating hormone (MSH). It is a fragment of the larger pro-opiomelanocortin (POMC) protein, which is produced by the pituitary gland. Melitane specifically mimics the actions of α-MSH, a peptide responsible for stimulating melanogenesis, the process by which the skin produces melanin, the pigment responsible for skin color.
Melitane is primarily used in cosmetic formulations aimed at enhancing skin pigmentation, improving skin tone, and providing a more even, sun-kissed appearance without the need for sun exposure or tanning. It has gained popularity due to its ability to stimulate melanin production, making it a key ingredient in skin-bronzing products and those designed to protect against UV damage.
How Does Melitane Work?
Acetyl Hexapeptide-1 works through its ability to bind to melanocortin receptors, particularly the MC1-R (Melanocortin 1 Receptor), which is found on melanocytes in the skin. When activated, these receptors trigger the production of melanin, leading to the pigmentation of the skin. Here’s how Melitane functions:
The primary mechanism of Melitane is the stimulation of melanogenesis. When Melitane binds to the MC1-R on melanocytes, it activates the production of melanin in the skin. Melanin is the pigment responsible for giving the skin its color, and the more melanin that is produced, the darker the skin becomes. Melitane effectively induces this process, leading to a gradual darkening of the skin, resulting in a tan-like appearance.
Unlike traditional tanning methods, which involve UV exposure and can damage the skin, Melitane helps create a natural, even tan by increasing melanin production without the need for sun exposure. This makes it a popular ingredient in sunless tanning products. It provides a gradual, even bronzed look, reducing the risk of the uneven pigmentation that can result from sun exposure or traditional tanning.
While Melitane itself does not provide direct protection from UV radiation, the increased melanin production it triggers can help offer a degree of natural UV protection. Melanin has photoprotective properties, meaning it helps absorb and dissipate UV radiation, protecting deeper layers of the skin from potential UV damage. This makes Melitane an excellent ingredient in products designed to enhance the skin’s natural defense mechanisms against sunlight.
As a peptide that increases melanin production, Acetyl Hexapeptide-1 may also help prevent some of the visible signs of sun-induced aging, such as photoaging (sun damage), fine lines, and wrinkles. By promoting a more uniform and protective pigmentation, Melitane can contribute to a youthful and radiant complexion while preventing hyperpigmentation, age spots, and other types of skin damage.
Melitane’s ability to promote an even and natural-looking tan contributes to a healthy, glowing appearance. Unlike some tanning methods that can leave the skin looking dull or orange, Melitane provides a more natural, bronzed look with a radiant, youthful glow.
Primary Uses of Melitane
Melitane is primarily used in products designed to provide a natural-looking tan without the need for sun exposure or artificial tanning methods. Some of the key products include:
Melitane can help improve overall skin tone by promoting even pigmentation. It is used in various skincare products aimed at:
While Melitane should not be considered a substitute for sunscreen, it can provide an additional layer of protection from UV damage. The melanin produced as a result of Melitane activation absorbs UV radiation and helps prevent the skin from burning, offering an indirect form of protection.
Melitane’s ability to enhance skin pigmentation also contributes to the prevention of photoaging—the premature aging of skin caused by sun exposure. By providing a more even and uniform skin tone, Melitane helps skin appear smoother and more youthful. Furthermore, the radiance-enhancing properties make the skin look fresh and glowing.
Scientific Research & Studies Supporting Melitane
A study published in the Journal of Investigative Dermatology (2006) explored the role of α-Melanocyte-Stimulating Hormone (Alpha-MSH) in regulating melanogenesis and skin pigmentation. The study found that α-MSH directly stimulates melanocytes to produce melanin, leading to increased pigmentation and a darker skin tone. This study laid the foundation for using Melitane as an effective agent in sunless tanning products.
Research in the Journal of Dermatological Science (2008) examined how melanin helps protect the skin from UV-induced damage. The study found that melanin not only provides pigmentation but also absorbs UV radiation, thereby reducing the harmful effects of UV exposure. This underscores the value of Acetyl Hexapeptide-1 in stimulating melanin production to enhance the skin’s natural defense against UV radiation.
A clinical study published in Skin Pharmacology and Physiology (2011) investigated the effect of Acetyl Hexapeptide-1 (α-MSH) on skin tone. The study showed that the peptide significantly enhanced skin pigmentation, providing a bronzed appearance similar to natural tanning, without the need for UV exposure. Participants experienced a noticeable increase in melanin production, leading to improved skin tone and a more even complexion.
Another study published in Cosmetic Dermatology (2013) looked at the use of peptides like Acetyl Hexapeptide-1 in skincare formulations aimed at enhancing skin radiance and glow. The research found that peptides that stimulate melanin production can contribute to a more vibrant, youthful skin appearance by improving overall skin tone and reducing the visible effects of photoaging.
Potential Benefits of Melitane
Dosage and Application
Acetyl Hexapeptide-1 is commonly found in topical skincare products like self-tanners, bronzers, and anti-aging creams. The concentration of Melitane in these products typically ranges from 0.01% to 0.1%, depending on the formulation. For best results, these products should be applied to clean, dry skin, usually once or twice a day. It’s important to follow the manufacturer’s instructions for optimal application and to perform a patch test before use to ensure skin compatibility.
Additional information
≥95.0%
870.03 g/mol
C43H59N13O7
Ac-Nle-Ala-His-D-Phe-Arg-Trp-NH2; XAHFRW
HPLC Acetyl Hexapeptide-1
COA Acetyl Hexapeptide-1
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