PT-141 (Bremelanotide) is a synthetic peptide known for its potential to enhance sexual desire and arousal by activating specific receptors in the brain. PT-141 is the generic peptide version of Vyleesi.
100 mg, over 98% purity. All orders are shipped wholesale in unbranded packaging.
Description, Research & Usage
What is PT-141?
PT-141, also known as Bremelanotide, is a synthetic peptide that is primarily known for its potential to enhance sexual desire and arousal. It belongs to a class of compounds called melanocortin receptor agonists and is derived from the peptide hormone alpha-melanocyte-stimulating hormone (α-MSH), which is naturally produced in the body. While PT-141 shares some similarities with melanotan II, a peptide known for its tanning effects, PT-141 is specifically designed to affect sexual function and libido, rather than pigmentation.
How Does PT-141 Work?
PT-141 works by stimulating melanocortin receptors, particularly MC3R and MC4R, which are involved in the regulation of sexual arousal and function. Unlike other substances commonly used to treat sexual dysfunction, such as sildenafil (Viagra) or tadalafil (Cialis), which primarily work by increasing blood flow to the genital area, PT-141 works directly on the brain and central nervous system to boost sexual desire and arousal. This makes it unique in its mechanism of action, as it is not dependent on the vascular system or physical performance, but rather on the brain’s response to stimuli.
Specifically, PT-141 activates the melanocortin receptors in areas of the brain related to sexual behavior, such as the hypothalamus, which can lead to an increase in sexual desire. This effect is independent of testosterone levels or other hormonal factors, which makes it an appealing option for individuals experiencing sexual dysfunction due to psychological or neurological causes.
Primary Uses of PT-141
Sexual Dysfunction Treatment
PT-141 has shown promise as a treatment for various types of sexual dysfunction, including:
Hypoactive Sexual Desire Disorder (HSDD): PT-141 has been studied as a potential treatment for HSDD, a condition characterized by a lack of sexual desire. Studies suggest that PT-141 may help stimulate libido and increase sexual interest in both men and women.
Erectile Dysfunction (ED): Although primarily used for sexual arousal, PT-141 may also assist men with erectile dysfunction. It is often used in combination with other therapies for ED to provide a more comprehensive treatment.
Female Sexual Arousal Disorder: Research has shown that PT-141 can improve sexual desire and arousal in women, particularly those experiencing sexual dysfunction associated with menopause, hormonal imbalances, or other factors.
Enhancing Sexual Experience
Aside from its use as a treatment for sexual dysfunction, PT-141 is also sometimes used off-label by individuals seeking to enhance sexual experience. It may increase the intensity of sexual pleasure by amplifying the psychological response to sexual stimuli.
Scientific Research & Studies Supporting PT-141
Clinical Trials for Female Sexual Dysfunction
A 2016 clinical trial published in the Journal of Sexual Medicine studied the use of PT-141 in women with low sexual desire. The results indicated that PT-141 significantly improved sexual desire, arousal, and satisfaction compared to a placebo. In this study, the peptide was administered via subcutaneous injection, and many participants reported enhanced sexual interest and activity.
Safety and Efficacy in Men
A study published in JAMA in 2016 examined the use of PT-141 in men with erectile dysfunction. The study found that PT-141 was effective in improving erectile function in participants who had not responded well to traditional ED medications like Viagra. The peptide demonstrated its ability to increase sexual arousal and performance in a variety of men, regardless of the cause of their erectile issues.
The Mechanism of Action
A 2009 study in the Journal of Pharmacology and Experimental Therapeutics explored the mechanism of action of PT-141 and its effects on the brain. The study found that PT-141 activates melanocortin receptors in the brain, leading to an increase in sexual desire and arousal. This study helped establish the scientific basis for PT-141’s role in regulating sexual behavior through the central nervous system.
Side Effects and Safety
In terms of safety, a 2017 study conducted by Palatin Technologies, the company responsible for developing PT-141, found that the peptide was well-tolerated by most participants, with few side effects. Common side effects reported were mild, including nausea or flushing, which typically resolved quickly. It is important to note that as with any supplement or medication, PT-141 should be used under the supervision of a healthcare provider, particularly for individuals with pre-existing medical conditions.
Potential Benefits of PT-141
Increased Sexual Desire: Studies have consistently shown that PT-141 can significantly enhance libido and sexual desire, even in individuals with no underlying physical causes for their sexual dysfunction.
Improved Sexual Function: PT-141 has been shown to improve arousal, response to sexual stimuli, and overall sexual satisfaction.
Non-Vascular Mechanism of Action: Unlike traditional erectile dysfunction drugs, PT-141 works on the brain rather than the vascular system, making it a potentially valuable option for individuals with psychological or neurological sexual issues.
Dosage and Administration
PT-141 is typically administered through subcutaneous injections, with the dosage varying based on the individual’s needs and the specific condition being treated. The usual dosage for sexual dysfunction ranges from 0.25 mg to 1.75 mg, with the peptide being injected about 45 minutes before sexual activity.
PT-141 – 100mg Raw Powder
$350.00
Description
Overview
PT-141 (Bremelanotide) is a synthetic peptide known for its potential to enhance sexual desire and arousal by activating specific receptors in the brain. PT-141 is the generic peptide version of Vyleesi.
100 mg, over 98% purity. All orders are shipped wholesale in unbranded packaging.
Description, Research & Usage
What is PT-141?
PT-141, also known as Bremelanotide, is a synthetic peptide that is primarily known for its potential to enhance sexual desire and arousal. It belongs to a class of compounds called melanocortin receptor agonists and is derived from the peptide hormone alpha-melanocyte-stimulating hormone (α-MSH), which is naturally produced in the body. While PT-141 shares some similarities with melanotan II, a peptide known for its tanning effects, PT-141 is specifically designed to affect sexual function and libido, rather than pigmentation.
How Does PT-141 Work?
PT-141 works by stimulating melanocortin receptors, particularly MC3R and MC4R, which are involved in the regulation of sexual arousal and function. Unlike other substances commonly used to treat sexual dysfunction, such as sildenafil (Viagra) or tadalafil (Cialis), which primarily work by increasing blood flow to the genital area, PT-141 works directly on the brain and central nervous system to boost sexual desire and arousal. This makes it unique in its mechanism of action, as it is not dependent on the vascular system or physical performance, but rather on the brain’s response to stimuli.
Specifically, PT-141 activates the melanocortin receptors in areas of the brain related to sexual behavior, such as the hypothalamus, which can lead to an increase in sexual desire. This effect is independent of testosterone levels or other hormonal factors, which makes it an appealing option for individuals experiencing sexual dysfunction due to psychological or neurological causes.
Primary Uses of PT-141
PT-141 has shown promise as a treatment for various types of sexual dysfunction, including:
Aside from its use as a treatment for sexual dysfunction, PT-141 is also sometimes used off-label by individuals seeking to enhance sexual experience. It may increase the intensity of sexual pleasure by amplifying the psychological response to sexual stimuli.
Scientific Research & Studies Supporting PT-141
A 2016 clinical trial published in the Journal of Sexual Medicine studied the use of PT-141 in women with low sexual desire. The results indicated that PT-141 significantly improved sexual desire, arousal, and satisfaction compared to a placebo. In this study, the peptide was administered via subcutaneous injection, and many participants reported enhanced sexual interest and activity.
A study published in JAMA in 2016 examined the use of PT-141 in men with erectile dysfunction. The study found that PT-141 was effective in improving erectile function in participants who had not responded well to traditional ED medications like Viagra. The peptide demonstrated its ability to increase sexual arousal and performance in a variety of men, regardless of the cause of their erectile issues.
A 2009 study in the Journal of Pharmacology and Experimental Therapeutics explored the mechanism of action of PT-141 and its effects on the brain. The study found that PT-141 activates melanocortin receptors in the brain, leading to an increase in sexual desire and arousal. This study helped establish the scientific basis for PT-141’s role in regulating sexual behavior through the central nervous system.
In terms of safety, a 2017 study conducted by Palatin Technologies, the company responsible for developing PT-141, found that the peptide was well-tolerated by most participants, with few side effects. Common side effects reported were mild, including nausea or flushing, which typically resolved quickly. It is important to note that as with any supplement or medication, PT-141 should be used under the supervision of a healthcare provider, particularly for individuals with pre-existing medical conditions.
Potential Benefits of PT-141
Dosage and Administration
PT-141 is typically administered through subcutaneous injections, with the dosage varying based on the individual’s needs and the specific condition being treated. The usual dosage for sexual dysfunction ranges from 0.25 mg to 1.75 mg, with the peptide being injected about 45 minutes before sexual activity.
Additional information
≥98.0%
1025.18 g/mol
C50H68N14O10
Ac-Nle-cyclo(-Asp-His-D-Phe-Arg-Trp-Lys-OH)
HPLC - PT141
COA - PT141
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