TB-500 (thymosin beta-4) is a natural peptide that promotes healing and recovery.
100 mg powder, over 98% purity. All orders are shipped wholesale in unbranded packaging.
Description, Research & Usage
What is Thymosin Beta-4?
Thymosin Beta-4 (Tβ4) is a naturally occurring peptide that plays a critical role in cellular regeneration, wound healing, and tissue repair. It is a member of the thymosin family of peptides, which were originally isolated from the thymus gland. Thymosin Beta-4 is a 43-amino acid peptide with powerful regenerative and anti-inflammatory properties, making it particularly valuable in the context of tissue repair, healing, and recovery.
This peptide has gained significant attention in both medical and cosmetic fields due to its potential to accelerate wound healing, promote tissue regeneration, and support the repair of damaged tissues, particularly in muscles, skin, and connective tissue. Thymosin Beta-4 is also being studied for its potential in treating various conditions, including chronic injuries, heart disease, and even neurological conditions.
How Does Thymosin Beta-4 Work?
Thymosin Beta-4 works through a variety of mechanisms that promote cellular regeneration, reduce inflammation, and enhance tissue repair. Here’s how it works:
Cellular Migration and Proliferation
Thymosin Beta-4 promotes the migration and proliferation of cells, particularly fibroblasts, which are the primary cells involved in tissue repair. By stimulating the movement of these cells to the site of injury, Thymosin Beta-4 helps accelerate the healing process. Fibroblasts are responsible for producing collagen and extracellular matrix (ECM) proteins, which are essential for the structural integrity of tissues during wound healing.
Collagen Synthesis and Tissue Repair
One of the key roles of Thymosin Beta-4 is to enhance collagen synthesis. Collagen is the main structural protein in connective tissues and plays a vital role in the repair of damaged tissues. Thymosin Beta-4 stimulates the production of collagen in fibroblasts, thus accelerating the healing of wounds, muscle injuries, and other tissue damage.
Anti-Inflammatory Effects
Thymosin Beta-4 has significant anti-inflammatory properties. By modulating the production of inflammatory cytokines, it helps reduce excessive inflammation at injury sites, which can impede the healing process. Its ability to control inflammation makes it particularly beneficial for conditions like tendinitis, arthritis, and muscle strains, where inflammation plays a key role in pain and delayed healing.
Angiogenesis (Blood Vessel Formation)
Thymosin Beta-4 has been shown to promote angiogenesis, the process by which new blood vessels are formed. This is important for tissue repair, as new blood vessels help deliver oxygen and nutrients to the damaged tissues, further enhancing the healing process. Increased angiogenesis is crucial for recovery from injuries like cuts, burns, and muscle strains.
Stem Cell Recruitment
Thymosin Beta-4 has been demonstrated to recruit stem cells to injury sites. These stem cells are essential for tissue regeneration and repair, as they can differentiate into various cell types, including muscle, skin, and bone cells. By encouraging stem cell migration to areas of damage, Tβ4 plays an important role in the body’s natural repair mechanisms.
Protective Effects on Tissues
Thymosin Beta-4 also has protective effects on tissues, particularly in high-stress environments like the heart and brain. It helps protect cells from oxidative stress, apoptosis (cell death), and other types of damage that may occur during trauma or injury. This protective role makes Tβ4 an interesting candidate for use in treating cardiovascular, neurological, and other chronic conditions.
Primary Uses of Thymosin Beta-4
Wound Healing and Tissue Repair
Thymosin Beta-4 is widely used in medicine and clinical settings for its ability to accelerate the healing of wounds, cuts, and injuries. It has been shown to significantly speed up the recovery process for:
Skin injuries (cuts, burns, surgical wounds)
Muscle injuries (strains, tears, and sprains)
Tendon and ligament injuries (e.g., Achilles tendon injuries)
Bone fractures (by supporting bone regeneration)
Corneal healing (in eye injuries and surgeries)
Sports Medicine and Muscle Recovery
Thymosin Beta-4 has gained popularity in sports medicine due to its ability to accelerate muscle and tendon recovery. Athletes often use Tβ4 to recover from strains, tears, or surgeries involving muscles, tendons, and ligaments. The peptide’s promotion of collagen synthesis and tissue regeneration helps speed up recovery times and enhances healing of musculoskeletal injuries.
Anti-Aging and Skin Regeneration
Due to its regenerative properties, Thymosin Beta-4 is also used in cosmetic and dermatological treatments. It can help with the following:
Wrinkle reduction: By promoting collagen production and skin regeneration, Tβ4 helps improve skin elasticity and reduce the appearance of fine lines and wrinkles.
Scar healing: Thymosin Beta-4 has been shown to reduce scar formation and promote more aesthetically pleasing healing of surgical or traumatic scars.
General skin rejuvenation: By stimulating cell turnover and promoting healing, Tβ4 can contribute to smoother, more youthful skin.
Cardiovascular Health
Thymosin Beta-4 has been studied for its potential to support heart health, especially following myocardial infarction (heart attack). Research has shown that Tβ4 can help promote heart tissue regeneration, prevent heart cell death, and encourage angiogenesis (the formation of new blood vessels) in damaged cardiac tissue.
Neurological Applications
Research has suggested that Thymosin Beta-4 may have potential therapeutic uses for brain injury, stroke recovery, and neurodegenerative diseases. Its ability to promote neurogenesis (the formation of new neurons) and protect brain cells from oxidative stress may offer hope for improving recovery from neurological injuries and conditions such as traumatic brain injury (TBI) and Alzheimer’s disease.
Scientific Research & Studies Supporting Thymosin Beta-4
Thymosin Beta-4 in Wound Healing
A study published in Wound Repair and Regeneration (2005) investigated the effects of Thymosin Beta-4 on wound healing in animal models. The results showed that Thymosin Beta-4 accelerated the healing of both acute and chronic wounds by promoting cell migration, collagen synthesis, and angiogenesis. The peptide was found to significantly shorten healing time and improve tissue regeneration.
Thymosin Beta-4 and Muscle Recovery
A study in The Journal of Clinical Investigation (2011) examined the effects of Thymosin Beta-4 on muscle regeneration following injury. The study found that Tβ4 enhanced muscle cell regeneration, reduced muscle fibrosis, and improved recovery in mice with muscle injuries. This has significant implications for sports medicine, where muscle repair is crucial for optimal recovery.
Cardiac Repair and Thymosin Beta-4
A study published in Nature (2005) demonstrated that Thymosin Beta-4 could promote heart tissue regeneration following a heart attack. The research indicated that Tβ4 stimulated the formation of new blood vessels and protected heart cells from damage, improving overall cardiac function after myocardial infarction.
Thymosin Beta-4 in Skin Regeneration
In a clinical trial published in Dermatologic Surgery (2007), Thymosin Beta-4 was shown to improve wound healing in human skin, reducing scar formation and enhancing the appearance of surgical wounds. The peptide’s ability to promote collagen production and accelerate tissue regeneration made it a promising candidate for improving skin health in both medical and cosmetic applications.
Potential Benefits of Thymosin Beta-4
Accelerated Wound Healing: Promotes faster recovery from skin injuries, cuts, burns, and surgical wounds.
Muscle and Tendon Recovery: Enhances recovery from muscle strains, tears, and tendon injuries, making it a popular choice in sports medicine.
Improved Skin Appearance: Reduces the appearance of wrinkles, scars, and signs of aging by promoting collagen production and skin regeneration.
Cardiovascular Support: Stimulates tissue regeneration and angiogenesis, offering potential benefits for heart health.
Neuroprotection and Recovery: May help in the treatment of neurological conditions by supporting brain cell regeneration and protecting against cell damage.
Dosage and Application
Thymosin Beta-4 is typically administered through subcutaneous injections in medical or clinical settings. Dosage can vary depending on the condition being treated, but typical protocols involve doses ranging from 1–2 mg per day for a specified period (often 7–14 days). It is important to consult with a healthcare provider for proper dosing and administration, especially for long-term use.
In cosmetic formulations, Thymosin Beta-4 can be found in creams, serums, and treatments designed to promote skin regeneration, collagen synthesis, and anti-aging effects.
TB-500 (TB-4) – 100mg Raw Powder
$240.00
Description
Overview
TB-500 (thymosin beta-4) is a natural peptide that promotes healing and recovery.
100 mg powder, over 98% purity. All orders are shipped wholesale in unbranded packaging.
Description, Research & Usage
What is Thymosin Beta-4?
Thymosin Beta-4 (Tβ4) is a naturally occurring peptide that plays a critical role in cellular regeneration, wound healing, and tissue repair. It is a member of the thymosin family of peptides, which were originally isolated from the thymus gland. Thymosin Beta-4 is a 43-amino acid peptide with powerful regenerative and anti-inflammatory properties, making it particularly valuable in the context of tissue repair, healing, and recovery.
This peptide has gained significant attention in both medical and cosmetic fields due to its potential to accelerate wound healing, promote tissue regeneration, and support the repair of damaged tissues, particularly in muscles, skin, and connective tissue. Thymosin Beta-4 is also being studied for its potential in treating various conditions, including chronic injuries, heart disease, and even neurological conditions.
How Does Thymosin Beta-4 Work?
Thymosin Beta-4 works through a variety of mechanisms that promote cellular regeneration, reduce inflammation, and enhance tissue repair. Here’s how it works:
Thymosin Beta-4 promotes the migration and proliferation of cells, particularly fibroblasts, which are the primary cells involved in tissue repair. By stimulating the movement of these cells to the site of injury, Thymosin Beta-4 helps accelerate the healing process. Fibroblasts are responsible for producing collagen and extracellular matrix (ECM) proteins, which are essential for the structural integrity of tissues during wound healing.
One of the key roles of Thymosin Beta-4 is to enhance collagen synthesis. Collagen is the main structural protein in connective tissues and plays a vital role in the repair of damaged tissues. Thymosin Beta-4 stimulates the production of collagen in fibroblasts, thus accelerating the healing of wounds, muscle injuries, and other tissue damage.
Thymosin Beta-4 has significant anti-inflammatory properties. By modulating the production of inflammatory cytokines, it helps reduce excessive inflammation at injury sites, which can impede the healing process. Its ability to control inflammation makes it particularly beneficial for conditions like tendinitis, arthritis, and muscle strains, where inflammation plays a key role in pain and delayed healing.
Thymosin Beta-4 has been shown to promote angiogenesis, the process by which new blood vessels are formed. This is important for tissue repair, as new blood vessels help deliver oxygen and nutrients to the damaged tissues, further enhancing the healing process. Increased angiogenesis is crucial for recovery from injuries like cuts, burns, and muscle strains.
Thymosin Beta-4 has been demonstrated to recruit stem cells to injury sites. These stem cells are essential for tissue regeneration and repair, as they can differentiate into various cell types, including muscle, skin, and bone cells. By encouraging stem cell migration to areas of damage, Tβ4 plays an important role in the body’s natural repair mechanisms.
Thymosin Beta-4 also has protective effects on tissues, particularly in high-stress environments like the heart and brain. It helps protect cells from oxidative stress, apoptosis (cell death), and other types of damage that may occur during trauma or injury. This protective role makes Tβ4 an interesting candidate for use in treating cardiovascular, neurological, and other chronic conditions.
Primary Uses of Thymosin Beta-4
Thymosin Beta-4 is widely used in medicine and clinical settings for its ability to accelerate the healing of wounds, cuts, and injuries. It has been shown to significantly speed up the recovery process for:
Thymosin Beta-4 has gained popularity in sports medicine due to its ability to accelerate muscle and tendon recovery. Athletes often use Tβ4 to recover from strains, tears, or surgeries involving muscles, tendons, and ligaments. The peptide’s promotion of collagen synthesis and tissue regeneration helps speed up recovery times and enhances healing of musculoskeletal injuries.
Due to its regenerative properties, Thymosin Beta-4 is also used in cosmetic and dermatological treatments. It can help with the following:
Thymosin Beta-4 has been studied for its potential to support heart health, especially following myocardial infarction (heart attack). Research has shown that Tβ4 can help promote heart tissue regeneration, prevent heart cell death, and encourage angiogenesis (the formation of new blood vessels) in damaged cardiac tissue.
Research has suggested that Thymosin Beta-4 may have potential therapeutic uses for brain injury, stroke recovery, and neurodegenerative diseases. Its ability to promote neurogenesis (the formation of new neurons) and protect brain cells from oxidative stress may offer hope for improving recovery from neurological injuries and conditions such as traumatic brain injury (TBI) and Alzheimer’s disease.
Scientific Research & Studies Supporting Thymosin Beta-4
A study published in Wound Repair and Regeneration (2005) investigated the effects of Thymosin Beta-4 on wound healing in animal models. The results showed that Thymosin Beta-4 accelerated the healing of both acute and chronic wounds by promoting cell migration, collagen synthesis, and angiogenesis. The peptide was found to significantly shorten healing time and improve tissue regeneration.
A study in The Journal of Clinical Investigation (2011) examined the effects of Thymosin Beta-4 on muscle regeneration following injury. The study found that Tβ4 enhanced muscle cell regeneration, reduced muscle fibrosis, and improved recovery in mice with muscle injuries. This has significant implications for sports medicine, where muscle repair is crucial for optimal recovery.
A study published in Nature (2005) demonstrated that Thymosin Beta-4 could promote heart tissue regeneration following a heart attack. The research indicated that Tβ4 stimulated the formation of new blood vessels and protected heart cells from damage, improving overall cardiac function after myocardial infarction.
In a clinical trial published in Dermatologic Surgery (2007), Thymosin Beta-4 was shown to improve wound healing in human skin, reducing scar formation and enhancing the appearance of surgical wounds. The peptide’s ability to promote collagen production and accelerate tissue regeneration made it a promising candidate for improving skin health in both medical and cosmetic applications.
Potential Benefits of Thymosin Beta-4
Dosage and Application
Thymosin Beta-4 is typically administered through subcutaneous injections in medical or clinical settings. Dosage can vary depending on the condition being treated, but typical protocols involve doses ranging from 1–2 mg per day for a specified period (often 7–14 days). It is important to consult with a healthcare provider for proper dosing and administration, especially for long-term use.
In cosmetic formulations, Thymosin Beta-4 can be found in creams, serums, and treatments designed to promote skin regeneration, collagen synthesis, and anti-aging effects.
Additional information
≥98.0%
889.02 g/mol
C₂₁₂H₃₅₀N₅₆O₇₈S
Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-[13C6]Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser
TB-500 (TB-4) COA
TB-500 (TB-4) HPLC
TB-4 Janoshik Test (Dec 2024)
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